Over the centuries bitter oranges were highly valued for their food and medicinal properties.*

In ancient China unripened bitter oranges were used to make zhi shi, an herbal extract used for constipation, to improve energy (chi) and to calm nerves in cases of insomnia and shock.*

In the Amazon rainforest indigenous tribes used bitter orange tea as a laxative and to relieve nausea, stomach pains, indigestion, gas and constipation.*